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DAPHNE aims to enhance disease research models by incorporating piezoelectric properties of tissues, particularly in idiopathic pulmonary fibrosis. This project will develop a platform that simulates electro-mechanical interactions, improving drug testing and understanding of cellular behavior in fibrotic conditions.
Tissues are piezoelectric materials, generating electrical signals in response to mechanical stress, and yet this important aspect has not yet been incorporated into the design of disease research models, particularly in conditions like idiopathic pulmonary fibrosis (IPF).
Piezoelectricity affects cellular migration, growth, and differentiation.
However, most of our understanding of cell-tissue interactions comes from studying cells under ‘static’ mechanical conditions.
Cells interact with their…
QUEEN MARY UNIVERSITY OF LONDON
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