CORDIS Project
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This project investigates the role of non-coding RNA, specifically antisense long non-coding RNAs, in gene regulation and their implications in development and disease. By cataloging these RNAs across various human cell types, the project aims to uncover their functional roles in gene expression and stability, particul…
98% of the human genome is non-protein coding raising the question of the role of the dark matter of the genome.
It is now admitted that pervasive transcription generates thousands of noncoding transcripts that regulate gene expression and have broad impacts on development and disease.
Among the long non coding (lnc)RNAs, antisense transcripts have been poorly studied despite their putative regulatory importance.
Several functional examples include X-chromosome inactivation, maintenance of pluri…
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