CORDIS Project
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This project explores the activation of dendritic cells in the immune system, focusing on how direct recognition of pathogens is essential for effective immune responses. It aims to identify the signals necessary for transforming resting dendritic cells into active antigen-presenting cells capable of priming T cell res…
During infection, recognition of the infectious microorganism by the innate immune system leads to dendritic cell (DC) activation.
This process is essential for the induction of antigen-specific adaptive immune responses. DC can be activated directly by conserved pathogen molecules or indirectly by inflammatory mediators released by other cell types that recognized such molecules.
However, recent studies revealed that inflammation cannot completely substitute for direct DC recognition of microbe…
CANCER RESEARCH UK LBG
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