CORDIS Project
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This project explores the mechanisms of immune response in allergy and asthma, focusing on dendritic cell activation. By studying how certain receptors influence T cell polarization, it aims to identify new therapeutic targets for treating inflammatory diseases linked to these conditions.
The immune response is a tightly regulated process which normally results in protection from infection and tolerance of innocuous environmental antigens.
However, in allergy and asthma, the activated immune response results in a chronic pro-inflammatory state characterized by T cell Th2 polarization to normally well-tolerated antigens resulting in tissue inflammation and tissue remodeling.
Dendritic cells (DCs) are essential for inducing activation and differentiation of effector CD4+ and CD8…
SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS
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