CORDIS Project
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This project explores the mechanisms of T cell activation through cross presentation by dendritic cells, focusing on the role of phagocytosis in cancer immunotherapy. It aims to develop new strategies for enhancing immune responses against tumors.
T cell cross priming (the initiation of CD8+ T cell responses to antigen that are not expressed by dendritic cells, DCs) requires the phagocytosis of antigens by DCs and their presentation on MHC class I molecules, a process referred to as “cross presentation”.
Here, we propose a series of integrated approaches to address the most fundamental mechanisms of cross presentation and explore the use of this process for translational purposes in human cancer.This proposal will pursue three main object…
INSTITUT CURIE
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