CORDIS Project
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This project investigates how specific immune cells in the gut contribute to the transmission of HIV-1 during anal intercourse. It aims to understand the role of these cells in viral uptake and the influence of semen on this process, using studies in both macaques and humans.
Worldwide a large proportion of all new cases of HIV-1 infection are due to anal sexual intercourse, being the anal/rectal as well as distal colonic mucosa a site of viral uptake and entry. I recently demonstrated that intestinal lamina propria resident DCs migrate towards and extend cellular processes between the tight junctions of columnar epithelium through a CCR5-dependent mechanism, take up R5 but not X4 HIV-1, and then transfer infection to susceptible T cells.
Although in mice CX3CR1+DCs…
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