CORDIS Project
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The project studies how dendritic cells navigate complex environments while carrying large materials to initiate immune responses. It aims to understand the mechanics of cell migration and the challenges faced by these immune cells in various physical conditions.
As immune sentinels, dendritic cells (DCs) must be able to ingest material and migrate to lymph nodes to present the processed antigen to T cells, and initiate the adaptive immune response, essential against pathogens or cancer.
This means that DCs must be able to navigate through complex environments with this ingested material of varying physical characteristics.
Preliminary data revealed that DCs deform and/or rotate large, ingested material to overcome occlusion from entering constriction po…
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