CORDIS Project
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This project investigates how cells manage DNA damage during replication, focusing on the role of ubiquitin in regulating DNA damage bypass mechanisms. It aims to uncover the processes that maintain genome stability and prevent disease by studying the integration of DNA repair and replication pathways.
This project aims at delineating the regulatory signaling processes that enable cells to overcome DNA damage during DNA replication, a major challenge to the integrity of the genome as the normal replication machinery is unable to replicate past DNA lesions.
This may result in collapse of the replication fork, potentially giving rise to gross genomic alterations.
To mitigate this threat, all cells have evolved DNA damage bypass strategies such as translesion DNA synthesis (TLS), involving low fi…
KOBENHAVNS UNIVERSITET
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