CORDIS Project
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This project investigates the DNA damage response, focusing on how short RNA species contribute to the activation of repair mechanisms at DNA damage sites. By understanding these processes, the research aims to enhance knowledge about DNA repair in relation to aging and cancer.
DNA, if damaged, cannot be replaced.
If not replaceable, it must be repaired.
The so-called “DNA damage response” (DDR) is a coordinate set of evolutionary conserved events that arrest the cell-cycle (DNA damage checkpoint function) in proliferating cells and attempts DNA repair.
Until DNA damage has not been repaired in full, cell proliferation is not resumed in normal cells.DNA damage is a physiological event.
Ageing and cancer are both associated with DNA damage accumulation.
In the past, we…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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