CORDIS Project
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This project investigates the role of small non-coding RNAs in the DNA damage response, crucial for repairing DNA and regulating cell proliferation in cancer. It aims to develop a therapeutic approach using antisense oligonucleotides to inhibit these RNAs, potentially offering a new treatment for specific tumor types.
The so-called “DNA damage response” (DDR) is a coordinated set of evolutionary-conserved events that, triggered upon DNA damage detection, arrests the cell-cycle and attempts DNA repair.
Recently, we have unveiled and reported that DDR activation depends on RNA.
We observed that DNA double-strand breaks (DSBs) trigger the local generation of small non-coding RNAs at the site of DNA damage carrying the sequence surrounding the damaged site.
These DDR RNAs (DDRNAs) are essential for DDR activati…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Italy, MILANO
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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