CORDIS Project
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The DEAllAct project explores the allosteric regulation of the enzyme ATP-phosphoribosyltransferase, which is crucial for histidine biosynthesis. It combines computational simulations and experimental studies to understand the enzyme's catalytic process and enhance its function through specific mutations.
Allosteric regulation of enzyme catalysis is widespread in nature and presents challenges and opportunities in synthetic biology.
The enzyme ATP-phosphoribosyltransferase (ATPPRT) catalyses the first step in histidine biosynthesis, and is subject to complex allosteric inhibition by histidine.
The short form of the enzyme, HisGS, is found in complex with a regulatory protein, HisZ.
Such regulatory protein has a dual function: it allosterically enhances catalysis by HisGS, and it binds histidine a…
UPPSALA UNIVERSITET
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