CORDIS Project
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This project examines how epithelial tubes become polarized from unpolarized cells, focusing on the role of cell adhesion forces. It utilizes mouse stem cell cultures and zebrafish models to study the mechanisms of tissue patterning during development.
One fundamental question in biology is how are epithelial tubes polarised from initially unpolarised cells to establish coherent tissues.
In this project, I will determine the role of cell-cell adhesion mediated force during de novo polarisation of epithelial tubes. I will use two models for the studies of this project.
First, I will use a mouse embryo stem cell (mESC) culture model that phenocopies the morphogenesis of the very early mammalian embryo during implantation, when the epiblast forms…
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