CORDIS Project
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This project examines the molecular mechanisms behind programmed cell death, focusing on how cells transition from survival to death pathways. It aims to identify the interactions between autophagy and apoptosis, and their implications for developmental processes.
A cell’s decision to die is governed by multiple input signals received from a complex network of programmed cell death (PCD) pathways, including apoptosis and programmed necrosis.
Additionally, under some conditions, autophagy, whose function is mainly pro-survival, may act as a back-up death pathway.
We propose to apply new approaches to study the molecular basis of two important questions that await resolution in the field: a) how the cell switches from a pro-survival autophagic response to a…
WEIZMANN INSTITUTE OF SCIENCE
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