CORDIS Project
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This project investigates the role of Sox6, a transcriptional repressor, in regulating cardiac gene expression and its interaction with muscle-specific microRNAs known as MyomiRs. By identifying Sox6's target genes and cofactors, the research aims to enhance understanding of cardiac hypertrophy and heart failure mechan…
MicroRNAs (miRNAs) negatively regulate gene expression by promoting mRNA degradation and inhibiting mRNA translation.
Recent studies have uncovered key roles of miRNAs as mediators of cardiovascular development and disease, but much remains to be learned about their mechanisms of action and regulation.
Dr.
Olson's lab has described a family of muscle-specific miRNAs, referred to as MyomiRs, which are encoded by introns of myosin heavy chain genes.
These three miRNAs (miR-208a, miR-208b, miR-499)…
UNIVERSITAETSKLINIKUM FREIBURG
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