CORDIS Project
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This project investigates the mechanisms of DNA replication stress and its impact on cell survival. It focuses on understanding how cells stabilize stalled replication forks and prevent irreversible damage, with implications for improving cancer therapies targeting checkpoint-deficient cells.
DNA replication is essential for cell proliferation.
Obstacles to replication generate replication stress by stalling replication forks.
In response to replication stress, cells activate the DNA damage checkpoint pathway that coordinates a cellular response to prevent DNA damage and ensure cell survival.
One essential function of the checkpoint is to stabilise stalled replication forks and ensure that replication will resume after obstacles are removed.
Specifically, the yeast checkpoint effecto…
THE FRANCIS CRICK INSTITUTE LIMITED
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