CORDIS Project
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The DeciphGYG project aims to understand the mechanisms of glycogen biosynthesis, focusing on the enzyme human glycogenin 1. By combining computational and experimental techniques, the project seeks to reveal how this enzyme functions and its implications for drug design targeting glycogen storage disease type XV.
The biosynthesis of glycogen - glycogenesis - represents a key glucose (and hence energy) storage process across a wide range of organisms.
Human glycogenin 1 (hGYG1) is one of the two primary enzymes that initiates the biosynthesis of glycogen, our energy reservoir.
It polymerizes a maltosaccharide chain covalently attached to an enzyme residue, Y195, via a stepwise glycosylation reaction.
In the reaction cycle, a dynamic conformational switch between ground and active states induced by one of…
UNIVERSITAT DE BARCELONA
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