CORDIS Project
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This project investigates how newly formed proteins influence the degradation of their corresponding messenger RNA (mRNA) during translation. It focuses on understanding a novel mechanism called peptide-mediated mRNA decay, particularly in the context of tubulin mRNAs, to explore its implications for gene regulation an…
Cells tightly regulate mRNA stability to ensure accurate gene expression across diverse cellular states and conditions.
Traditionally, selective mRNA degradation has been attributed to the recognition of nucleotide sequence elements by proteins or small RNAs that subsequently recruit decay factors.
Conversely, an emerging mechanism termed “peptide-mediated mRNA decay” (PMD) involves the encoded protein: my postdoctoral work revealed how the nascent polypeptide—physically linked to the mRNA durin…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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