CORDIS Project
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This project investigates the early stages of heart formation using human heart organoids to understand the gene regulatory network involved in heart development. By analyzing gene expression and enhancer usage, it aims to uncover how mutations affect heart formation and contribute to heart diseases.
The early steps of heart formation during embryogenesis require precise spatiotemporal coordination between different heart progenitors to join together to form a beating heart tube.
This complex biological process is regulated through an evolutionary conserved gene regulatory network (GRN) of transcription factors and cis-regulatory elements that integrate inductive signals from surrounding tissues to ensure correct heart development.
Yet, how this process is controlled during heart development…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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