CORDIS Project
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This project explores how genetic mutations and environmental factors contribute to the evolution of the Leishmania parasite, which causes severe human infections. By studying genome instability and its effects on gene expression, the research aims to uncover mechanisms that enhance the parasite's adaptability and fitn…
Darwinian evolution plays a central yet poorly understood role in human disease.
Iterations between genetic mutation and environmental selection drive cancer development, microbial infection and therapeutic failure, thus increasing human mortality.
The molecular mechanisms that harness the deleterious effects of genome instability to generate beneficial phenotypes in these pathogenic systems are unknown.
Here we investigate this important unsolved question in the protozoan parasite Leishmania th…
INSTITUT PASTEUR
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