CORDIS Project
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This project introduces FUNC-NGS, a technique that links protein activity to DNA sequences using next generation sequencing. It aims to enhance drug discovery and therapeutic protein development through a novel screening approach.
Next generation sequencing (NGS) has become an indispensable tool for system biology and has recently been adopted in protein engineering science as well.
This proposal describes the development of a highly generalizable technique, termed FUNC-NGS, which links in situ functional information of protein activity with the function-determining DNA sequence in a massively parallel manner opening exciting possibilities, e.g., in drug discovery.
In this method a cell-free display platform is combined w…
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