CORDIS Project
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The DeepGlue project seeks to understand the interactions between molecular glues and proteins to improve targeted therapies for diseases like cancer. It aims to create a comprehensive atlas of resistance mutations to enhance drug design and efficacy.
Interactions between proteins and small molecules are rich in nature – across organisms, tissues and cellular contexts they underly crucial biological functions in health and disease.
One class of small biochemicals, molecular glues (MGs), can selectively induce de novo protein-protein dimerization.
Particularly in the context of targeted protein inhibition and degradation, MGs are praised as clinical alternatives to treating diseases driven by proteins that are otherwise pharmacologically intra…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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