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The DeepRibosome project focuses on determining the structures of dynamic ribosomal machines and their conformational changes during translation. By utilizing a novel in vitro system, it aims to capture real-time interactions and mechanisms of translation, providing insights into how various factors influence this esse…
Structure determination of dynamic macromolecular molecular machines and elucidating their conformational landscapes are fundamental tasks of structural biology.
The ribosome as a paradigmatic macromolecular machine interacts with numerous ligands and factors throughout its functional cycles, which in turn are driven and regulated by various conformational modes.
Project DeepRibosome proposes a new way to perform structural studies.
It is based on our recent finding that E. coli ex-vivo derived…
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