CORDIS Project
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This project investigates the mechanisms of DNA repair, specifically homologous recombination, to understand how cells maintain genomic integrity. Using yeast as a model, it aims to identify the components and interactions within DNA repair complexes that are crucial for preventing genetic diseases.
The integrity of a cell's genome is constantly challenged by DNA lesions such as base modifications and DNA strand breaks. A single double-strand break is lethal if unrepaired and may lead to loss-of-heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly.
Such genetic alterations are the main cause of cancer and other genetic diseases.
Homologous recombination is an error-free pathway for repairing DNA lesions such as single- and double-strand bre…
KOBENHAVNS UNIVERSITET
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