CORDIS Project
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This project explores how plasmids, which carry antibiotic resistance genes, evade bacterial defenses during gene transfer. By studying plasmid-encoded anti-defense systems, it aims to enhance our understanding of microbial interactions and develop new biotechnological applications.
The microbial world's genomic arms race spurred a remarkable diversity of defense and anti-defense mechanisms, with CRISPR-Cas and anti-CRISPR systems as prime examples that revolutionized genome editing.
Recent years have seen a surge in the discovery of bacterial anti-phage systems and their viral countermeasures, yet little is known about how plasmids—key vectors of antibiotic resistance—overcome host defenses.
Our lab recently found that plasmids' leading regions, the first to enter recipien…
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