CORDIS Project
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This project investigates the ubiquitin-proteasome system's role in regulating membrane proteins, which are crucial for many cellular functions and drug targets. By focusing on the E3 ligase gp78, the project aims to uncover the mechanisms of substrate detection and ubiquitination, enhancing our understanding of membra…
The ubiquitin-proteasome system (UPS) is responsible for the degradation of approximately 80% of proteins, enabling precise control of protein quality and maintaining protein homeostasis within the cell.
Over the past four decades, a comprehensive understanding of the regulatory mechanisms governing the UPS, particularly concerning various cytosolic and nuclear proteins has been developed.
However, there remains significant knowledge gaps regarding how membrane proteins, which account for one-th…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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