CORDIS Project
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This project explores the role of Cancer Associated Fibroblasts in breast cancer, particularly their influence on inflammation and metastasis. Using a mouse model, it aims to elucidate how these fibroblasts contribute to tumor progression and the metastatic process.
Breast cancer is one of the leading causes of cancer related mortality in women in the western world and inflammation is correlated with bad prognosis in breast cancer.
Breast tumors are characterized by an extensive desmoplastic stroma, abundantly populated by fibroblasts.
Cancer Associated Fibroblasts (CAFs) have been shown to promote the growth of mammary tumors by directly stimulating tumor cell proliferation and by enhancing angiogenesis, but their role in mediating inflammation in breast t…
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