CORDIS Project
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The DEFLAMMATION project investigates the complex signaling networks that regulate inflammation in the immune system. By developing innovative cell biology tools, it aims to identify key molecular players that can downregulate inflammation, with potential implications for treating autoinflammatory diseases.
The innate immune system evokes inflammation to control pathogens or damage.
Sophisticated mechanisms interpret molecular triggers to activate inflammasomes or transcription of pro-inflammatory genes.
While numerous autoinflammatory conditions underline the need to control inflammation, we still rely on simplistic models to understand its negative regulation. I hypothesize that an intricate signaling network interprets information to prevent or downregulate inflammation.
Understanding these so f…
UNIVERSITATSKLINIKUM BONN
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