CORDIS Project
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This project focuses on developing new therapeutic molecules called PROteolysis TArgeting Chimeras (PROTACs) that induce the degradation of disease-related proteins. By exploring the DCAF family of E3 ligases, the project aims to expand the toolbox for targeted protein degradation, potentially increasing treatment opti…
PROteolysis TArgeting Chimeras (PROTACs) are molecules with therapeutic potential that induce degradation of target proteins involved in disease. PROTACs are composed of a ligand that binds an E3 ubiquitin ligase, chemically linked to a ligand for the target protein.
Formation of a ternary complex between ligase, PROTAC and target protein leads to ubiquitination of the target, which is then recognised by the proteasome and degraded.
The vast majority of PROTAC degraders developed to date recruit…
UNIVERSITY OF DUNDEE
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