CORDIS Project
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This project aims to create better mouse models for Alzheimer's disease by focusing on DNA repair mechanisms and aging. It explores the connection between DNA damage and neurodegeneration, with potential nutritional interventions to delay cognitive decline.
Alzheimer’s disease (AD) affects worldwide ~50 million people.
Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD.
Age is the most determining factor in AD, but is poorly represented i…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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