CORDIS Project
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This project focuses on developing a new method to convert pyridines into benzonitriles, which are valuable compounds in drug discovery. The innovative approach involves a three-step process that utilizes photochemistry to facilitate this transformation, enhancing the efficiency of medicinal chemistry.
Bioisosteric replacement is crucial to drug discovery.
However, substituting a central core ring structure generally requires de novo synthetic sequences due to the lack of “ring-replacing” strategies that can be used at a late-stage.This project will focus on finding a solution to the challenge of converting pyridines into benzonitriles.
This is a desirable “ring replacement” in medicinal chemist and benzonitriles can mimic pyridines' properties and are effective bioisosteres.
However, current…
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
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