CORDIS Project
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DescendPain investigates how the brain modulates pain through specific neuron types in the Rostral Ventromedial Medulla. By utilizing advanced genetic and single-cell sequencing techniques, the project aims to uncover the cellular mechanisms behind pain modulation influenced by various affective states, ultimately seek…
Pain is a large societal and health problem.
Although often thought of as an invariant representation of active nociceptors, pain varies a lot under the influence of different affective states, sometimes with near complete analgesia.
Such modulation of pain is thought to occur through a descending pathway originating in the brain and to be executed by Rostral Ventromedial Medulla (RVM) neurons that project to the spinal cord.
Deciphering the complexity of the cell types involved and how they con…
KAROLINSKA INSTITUTET
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