CORDIS Project
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This project investigates the interactions between α-synuclein protein aggregates and cellular membranes to understand their role in neurodegenerative diseases like Parkinson's. It aims to develop advanced probes to monitor these interactions and assess their impact on neuronal health.
Formation and deposition of fibrillar protein aggregates (amyloids) is a fundamental feature of neurodegenerative diseases.
It has been suggested that neurotoxicity in Parkinson’s disease originates from the binding of α-synuclein (AS) oligomers to cellular membranes, resulting in bilayer disruption and leakage.
Membrane binding is also presumed to be involved in the (as yet unknown) physiological function(s) of AS.
Thus, it is essential to assess: (i) the diverse conformational states of AS bou…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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