CORDIS Project
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This project investigates the role of endothelial cells in tumor immunity, focusing on immunosuppressive genes that may hinder cancer treatment. By identifying and targeting these genes, the research aims to enhance the effectiveness of immunotherapy against various cancers.
Despite significant medical advancements, cancer remains a major cause of mortality worldwide, and several cancer types still lack efficient therapy, in part due to resistance to traditional immunotherapy (IT).
Endothelial cells (ECs) present an important yet overlooked modulator of tumor immunity, possessing an immunosuppressive nature, and proposed to contribute to IT resistance.
Studies of the host lab indeed identified immunomodulatory features in EC subsets (coined IMECs).
My central hypoth…
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