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DETRIMODE focuses on creating a method for developing molecules that can induce the degradation of specific proteins linked to diseases. These molecules are designed to recruit the cellular degradation system to target and eliminate harmful proteins.
The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins.
TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ub…
NERVIANO MEDICAL SCIENCES S.R.L
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