CORDIS Project
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This project aims to enhance microscopy techniques by utilizing deuterium to create advanced imaging probes. It focuses on super-resolution imaging in live cells, enabling detailed observation of proteins and drug interactions without genetic modifications, thus advancing applications in cell biology and drug developme…
The ideal microscopy experiment would take place in native cells without genetic engineering, with 3-dimensional resolution on the single molecule scale (<10 nm) by observing the endogenous molecule itself.
I propose the introduction and use of deuterium (“deuterON”) as a general method for a multimodal approach, to i) synthesize a first-in-class deuterated cyanine (Cy) fluorophore for super-resolution imaging, ii) to design and test deuterated, next-level photoswitches to restore vision, and i…
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