CORDIS Project
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This project investigates the mechanisms of tissue boundary formation during zebrafish development. By utilizing live imaging and genetic manipulation, it aims to understand how progenitor cells differentiate and establish boundaries, contributing to our knowledge of embryonic development and potential disease links.
During animal development, boundaries need to be reliably established between cell types to guarantee the physical and functional integrity of tissues.
This process requires delicate orchestration of cell proliferation, differentiation and migration, and defects in tissue boundary formation are often linked with abnormal cell behaviours in diseases.
Genetic programs involved in cell signalling and cell sorting across tissue boundaries have been previously identified, yet we still lack a systemat…
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