CORDIS Project
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This project investigates the dual role of dendritic cells in immunity and cancer. It aims to understand how transformed dendritic cells may evade immune control, using a genetically-engineered mouse model to study tumor development and immune interactions.
Dendritic cells (DC) are powerful antigen-presenting cells that can induce antigen-specific adaptive immunity to pathogens but also protective immunity against transformed self, i.e. cancer.
This crucial role of DC makes them an attractive target in cancer vaccination.
However, DC can also negatively regulate immunity by inducing antigen-specific tolerance and are a target in immunomodulatory approaches aimed at dampening autoimmunity or allergy.
Given this dual role in immunity and tolerance it…
THE FRANCIS CRICK INSTITUTE LIMITED
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