CORDIS Project
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The project aims to develop chemical methods for selectively modifying and tagging specific DNA modifications, particularly N6-methyladenine. It seeks to create a detailed mapping of this modification in genomic DNA, which is crucial for understanding its biological significance.
Herein, I propose to develop and adapt chemistry for the selective modification and tagging of N6-methyladenine (N6MeA) in the context of a DNA strand.
Two promising chemical strategies will be applied, for which I have already established proofs-of-concept of efficiency and selectivity on DNA monomers (2'-deoxynucleosides and nucleotides).
Once such a specific chemical labelling protocol has been optimised, I will use it to map N6MeA in genomic DNA with two different approaches: 1) by chemical…
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