CORDIS Project
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This project aims to explore how bacteria in the gut communicate using a signaling molecule called Autoinducer-2. By developing chemical tools to enhance beneficial bacterial responses and inhibit pathogens, the research seeks to promote a healthier gut microbiota.
Quorum sensing allows bacteria to synchronise and regulate their behaviours.
Autoinducer-2 (AI-2) is a particularly relevant signaling molecule able to promote inter-species communication.
In the mammalian gut microbiota, a therapeutically relevant niche, interference of AI-2-mediated signaling has been shown to influence the balance of the major phyla after antibiotic treatment.
Still, the mechanisms involved in this process are not known.
We propose to establish novel chemical and structural…
UNIVERSIDADE NOVA DE LISBOA
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