CORDIS Project
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This project investigates the role of the ubiquitin-proteasome system in cancer development. It aims to uncover how specific ubiquitin ligases contribute to tumorigenesis by identifying their substrates and understanding their interactions with tumor suppressor proteins.
The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data indicates that defects in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis.
The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of SCF ubiq…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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