CORDIS Project
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This project investigates the mechanisms by which specific peptides from preproinsulin trigger immune responses in Type 1 Diabetes. It focuses on the unconventional processing pathways of these peptides, aiming to uncover new therapeutic targets for managing the disease.
Type 1 Diabetes (T1D) is a chronic autoimmune disease in which pancreatic beta cells are selectively destroyed by autoreactive CD8+ cytotoxic T lymphocytes (CTLs).
The identification of the epitopes presented by “diabetogenic” HLA molecules to these CTLs constitutes a major research target to understand how beta cells are killed.
Preproinsulin (PPI) has emerged as a key autoantigen in T1D: a surprising finding made in the host laboratory is that the dominant HLA-A2.1-restricted-PPI epitope, PPI…
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