CORDIS Project
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This project develops a diagnostic kit to assess the efficiency of DNA mismatch repair, which is crucial for cancer prevention. It aims to identify individuals at risk of Lynch syndrome through a simplified, one-step test that detects decreased mismatch repair capacity in normal tissue, rather than relying on tradition…
Our original ERC project shows that a biological system which corrects errors arising during DNA replication (DNA mismatch repair, MMR) plays a crucial role in cancer avoidance.
We aim to conduct a proof of concept of the idea that functional assessment of MMR efficiency can be used to recognize individuals with decreased MMR capacity (i.e., Lynch syndrome).
The projected outcome is a diagnostic kit that can be used by health care providers.
Individuals whose test result indicates abnormality wo…
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