CORDIS Project
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This project investigates the dual role of the enzyme indoleamine 2,3-dioxygenase in immune regulation and metabolism. It aims to explore its conformational changes to identify new therapeutic strategies for autoimmune diseases and cancer.
Catabolism of amino acids is an ancient survival strategy that also controls immune responses in mammals.
Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, is recognized as an authentic regulator of immunity in several physiopathologic conditions, including autoimmune diseases, in which it is often defective, and neoplasia, in which it promotes immune unresponsiveness.
The PI’s group recently revealed that IDO does not merely degrade tryptophan and produce immunoregulatory kyn…
UNIVERSITA DEGLI STUDI DI PERUGIA
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