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DILEMMA focuses on understanding the relationship between diabetes mellitus and mechanical properties of tissues. By combining advanced imaging techniques with protein biochemistry, the project aims to identify new biomarkers linked to tissue stiffening and protein modifications, which could enhance diagnostic and ther…
DILEMMA will orient fundamental research to fill a gap in diabetes mellitus (DM) biology, by addressing a relevant biomedical problem in a cross-disciplinary manner, with great societal and economic impact. I will use a unique combination of advanced nanoscopy with protein biochemistry and cell biology.
Clinical studies identified stiffening in vascular, muscle and connecting tissues as particular mechanical fingerprints for DM.
In diabetic patients advanced glycation end products are clinical b…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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