CORDIS Project
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This project develops a digital biophysics platform using microfluidics and single molecule spectroscopy to study protein aggregation at the level of individual aggregates and cells. It aims to uncover the fundamental physical principles governing the formation and behavior of protein clusters, which are linked to neur…
Proteins are the fundamental building blocks of life, underpinning functional processes in living systems.
They are able to exert their biological activities by binding to other proteins to form functional complexes which act as the machinery of life.
In certain cases, however, proteins escape cellular quality control mechanisms and form aberrant complexes.
The formation of such clusters stabilised by inter-molecular hydrogen bonds, amyloid aggregates, has dramatic consequences for biological sy…
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