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The DIRECT-DSB project investigates how transcription influences the pattern of DNA double-strand breaks during meiosis in the unicellular organism Tetrahymena thermophila. By manipulating transcription in the meiotic nucleus, the project aims to clarify the relationship between transcription and DNA damage, contributi…
Meiosis is a specialized cell division process for producing gametes, and meiotic defects frequently cause infertility or birth defects (e.g.
Down syndrome).
Successful meiosis is ensured by the induction of hundreds of DNA double-strand breaks (DSBs) at the correct chromatin sites.
The pattern of DSBs is suggested to be controlled by some special chromatin features that are established upon transcription.
However, as transcription is essential for life, it is difficult to directly study whether…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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