CORDIS Project
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This project focuses on enhancing ketoreductases for the production of optically pure secondary alcohols, crucial for pharmaceuticals. By using gel-shell beads for enzyme screening, it aims to improve efficiency in biocatalysis and green chemistry.
Optically pure secondary alcohols are required in the manufacture of many pharmaceutical products.
Ketoreductases (KREDs) capable of reduction of ketones to the corresponding secondary alcohol have been improved through classical directed evolution campaigns but a limiting factor has always been the challenge of matching selection conditions to the final scaled-up reaction.
Here we propose a solution to that problem.
The Host group previously described the formation of gel-shell beads, agarose…
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