CORDIS Project
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This project develops an automated microfluidic device coupled with a mass spectrometer to analyze single-cell metabolic profiles. It aims to understand how clonal cell populations, like E. coli and S. cerevisiae, adapt to nutrient stress and generate resistant phenotypes through metabolic feedback mechanisms.
Cells can display different variations in behavior toward different external cues.
The multidisciplinary field of metabolomics provides a unique insight into the molecular feedbacks and cross-talk between metabolic cascades that allow organisms to adapt toward different sources of biotic and abiotic stress.Unfortunately, there is still a substantial technological limitation (in terms of sensitivity and throughput), when trying to understand the complex and highly interrelated metabolic processes…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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