CORDIS Project
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This project investigates the interactions between pancreatic cancer cells and surrounding stromal cells. By studying these interactions, it aims to understand how they influence cancer progression and treatment resistance, which could lead to better therapeutic strategies.
Pancreatic ductal adenocarcinomas (PDA) are complex heterocellular tumours characterised by extensive desmoplasia.
Tumour and stromal host cells actively engage to establish reciprocal signalling loops, which drive cancer progression, resistance to treatment and evasion of immune surveillance.
However, the specificity and directionality of these interactions are incompletely characterised.
We have previously shown that tumour cells expressing the main oncogenic driver (KRASG12D) co-opt stromal f…
THE UNIVERSITY OF MANCHESTER
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