CORDIS Project
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This project investigates chromothripsis, a phenomenon where multiple chromosome rearrangements occur in a single event, challenging traditional views of cancer progression. By analyzing human cell lines with persistent DNA damage, the research aims to uncover the mechanisms behind these chromosomal alterations and the…
Cancer is commonly thought as a progressive process, requiring accumulation of many mutations over time.
Recently, this conventional view of cancer progression has been challenged with the discovery of a phenomenon called chromothripsis, whereby tens to hundreds of chromosomal rearrangements occur in a single catastrophic event.
Despite the growing amount of sequencing data that sheds some light on the nature of these structural variations, the molecular mechanisms behind these detrimental alter…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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